Univ.-Prof. Dr. Eva Rohde
EV-TT Deputy Project Head PMU
Paracelsus Medical University - Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Transfer Center for Extracellular Vesicles - Theralytic Technologies
UIT - Department of Transfusion Medicine
Director: Univ.-Prof. Dr. Eva Rohde
The Department for Transfusion Medicine is producing about 5000 platelet concentrates per year for treatment of thrombocytopenia. Since 2013, the preparation of pooled human platelet lysate (pHPL) under GMP conditions using expired platelet concentrates has been established. This raw material represents an efficient alternative for fetal calf serum, enabling animal serum-free propagation of stromal cells and EVs for therapeutical application. [see homepage]
Research
- Platelet-derived extracellular vesicles (PEVs) contribute to hemostasis but are also supposed to be involved in wound healing. Our first research objective is to isolate and characterize PEVs from platelet concentrates and human platelet lysate. Second, we will investigate their physiological role for tissue regeneration, angiogenesis and immune modulation.
Transfer
- protocols for efficient isolation, characterization and cryopreservation of PEVs
- preparation of highly standardized “off-the shelf” PEV products
Team and Contact
a.o. Univ.-Prof. Dr. Katharina Schallmoser, MSc
+43 57255 24599 k.schallmoser@salk.at
EV-TT Member of the PMU Consortium
Paracelsus Medical University - Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS)
Transfer Center for Extracellular Vesicles - Theralytic Technologies